2,6-Dimethoxy-4-hydroxybenzaldehyde → 4-((1E)-2-(((E)-4-hydroxy-2,6-dimethoxystyrylsulfonyl)methylsulfonyl)vinyl)-3,5-dimethoxyphenol

HRID 557107Notes

Reaction equation

HRID 557107 reaction equation
[OH:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:5]([CH:6]=O)=[C:4]([O:12][CH3:13])[CH:3]=1.C([CH2:17][S:18]([CH2:21][S:22]([CH2:25][C:26](O)=O)(=[O:24])=[O:23])(=[O:20])=[O:19])(O)=O>C(O)(=O)C>[OH:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:5](/[CH:6]=[CH:17]/[S:18]([CH2:21][S:22](/[CH:25]=[CH:26]/[C:5]2[C:4]([O:12][CH3:13])=[CH:3][C:2]([OH:1])=[CH:9][C:8]=2[O:10][CH3:11])(=[O:23])=[O:24])(=[O:19])=[O:20])=[C:4]([O:12][CH3:13])[CH:3]=1

Participants

4

Reactant 2

HCID 5298942,6-Dimethoxy-4-hydroxybenzaldehydeHCID 2252641Acetic acid, 2,2'-[methylenebis(sulfonyl)]bis-

Product 1

HCID 116203114-((1E)-2-(((E)-4-hydroxy-2,6-dimethoxystyrylsulfonyl)methylsulfonyl)vinyl)-3,5-dimethoxyphenolYield 62%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 4-hydroxy-2,6-dimethoxybenzaldehyde (2 mmol) and carboxymethane-sulfonylmethanesulfonyl-acetic acid (1 mmol) in acetic acid (10 mL) was subjected to General Procedure 1, to yield the title compound in 62% yield. m.p. 148-150° C.

Sources & evidence

ORD record
ord-9709759630ff470e8f2d8eea6e19f9a0
Source dataset
uspto-grants-2011_11
Patent number
US08058313B2

Reaction notes

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