反应详情

温度

0 °C

α-Lactose (2.3 g, 6.38 mmol) was dissolved in 30 ml of anhydrous pyridine, benzoyl chloride (8.9 ml, 76.6 mmol) was added thereto at 0° C., and the mixture was stirred for 8 hrs at room temperature. After the reaction was completed, the reaction mixture was extracted with ethyl acetate, and successively washed with 1 N HCl, saturated NaHCO3 and brine. The extract was dried over MgSO4, concentrated under a reduced pressure, and purified by column chromatography (ethyl acetate:n-hexane=1:3), to obtain the title compound as a white solid (7.19 g).

1. extractionthe reaction mixture was extracted with ethyl acetate
2. washsuccessively washed with 1 N HCl, saturated NaHCO3 and brine
3. dry with materialThe extract was dried over MgSO4
4. concentrationconcentrated under a reduced pressure
5. custompurified by column chromatography (ethyl acetate:n-hexane=1:3)