Lawesson's reagent → 4-Quinazolinethiol

HRID 557119Notes

Reaction equation

HRID 557119 reaction equation
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=O)[N:3]=[CH:2]1.N1C=CC(=O)N=C1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:28])=CC=1>>[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[S:28])[N:3]=[CH:2]1

Participants

4

Reactant 3

HCID 87949Lawesson's reagentHCID 178516534HCID 178516534, compoundHCID 178518216HCID 178518216, compound

Product 1

HCID 7360904-Quinazolinethiol

Procedure

In the next step the carbonyl function of the 1H-quinazolin-4-one derivative, or the 1H-pyrimidin-4-one derivative with a condensed 5-membered heterocyclic ring structure is reacted further e.g. with phosphorous pentasulfide or Lawesson's reagent to yield the 1H-quinazolin-4-thion derivatives, or the 1H-pyrimidin-4-thion one derivatives with a condensed 5-membered heterocyclic ring structure.

Sources & evidence

ORD record
ord-d7a61baa0ed44b7caf74d42debb58e23
Source dataset
uspto-grants-2011_11
Patent number
US08058431B2

Reaction notes

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