HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 557126Generated: October 30, 2026
Ammonia → 4,5-Dimethoxy-2-(methylamino)benzamide
https://huagongshe.com/reaction/557126
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 6,7-Dimethoxy-1-methyl-1H-benzo(d)(1,3)oxazine-2,4-dione | HCID 12223292 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4,5-Dimethoxy-2-(methylamino)benzamide | HCID 66991473 | — |
Reaction Steps
2.40 g (10.1 mmol) 6,7-Dimethoxy-1-methyl-1H-benzo(d)(1,3)oxazine-2,4-dione were dissolved in 30 ml tetrahydrofuran and 15.0 ml ammonia (25%) added at 0° C. The solution was stirred for 30 min at 0° C. and for 30 min at room temperature. THF was distilled under vacuum and the remaining suspension was neutralized with diluted hydrogen chloride acid. The product was isolated by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08058431B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-e14b0866384940d0b705f500d9e9eca2 |
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| Source note | uspto-grants-2011_11 |
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