Ammonia → 4,5-Dimethoxy-2-(methylamino)benzamide
Reaction equation
[CH3:1][O:2][C:3]1[C:15]([O:16][CH3:17])=[CH:14][C:6]2[N:7](C)[C:8](=O)[O:9][C:10](=O)[C:5]=2[CH:4]=1.[NH3:18]>O1CCCC1>[CH3:17][O:16][C:15]1[C:3]([O:2][CH3:1])=[CH:4][C:5]([C:10]([NH2:18])=[O:9])=[C:6]([NH:7][CH3:8])[CH:14]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
2.40 g (10.1 mmol) 6,7-Dimethoxy-1-methyl-1H-benzo(d)(1,3)oxazine-2,4-dione were dissolved in 30 ml tetrahydrofuran and 15.0 ml ammonia (25%) added at 0° C. The solution was stirred for 30 min at 0° C. and for 30 min at room temperature. THF was distilled under vacuum and the remaining suspension was neutralized with diluted hydrogen chloride acid. The product was isolated by filtration.
Workup
- distillationTHF was distilled under vacuum
- customThe product was isolated by filtration
Sources & evidence
- ORD record
- ord-e14b0866384940d0b705f500d9e9eca2
- Source dataset
- uspto-grants-2011_11
- Patent number
- US08058431B2
Reaction notes
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