Ammonia → 5-Methoxy-2-methylamino-benzamide
Reaction equation
[CH3:1][O:2][C:3]1[CH:15]=[CH:14][C:6]2[N:7](C)[C:8](=O)[O:9][C:10](=O)[C:5]=2[CH:4]=1.[NH3:16]>O1CCCC1>[CH3:1][O:2][C:3]1[CH:15]=[CH:14][C:6]([NH:7][CH3:8])=[C:5]([CH:4]=1)[C:10]([NH2:16])=[O:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
1.50 g (7.24 mmol) 6-Methoxy-1-methyl-1H-benzo(d)(1,3)oxazine-2,4-dione were dissolved in 20 ml tetrahydrofuran and 10.0 ml ammonia (25%) added at 0° C. The solution was stirred for 30 min at 0° C. and for 30 min at room temperature. THF was distilled under vacuum and the remaining suspension was neutralized with diluted hydrogen chloride acid. The product was isolated by filtration.
Workup
- distillationTHF was distilled under vacuum
- customThe product was isolated by filtration
Sources & evidence
- ORD record
- ord-8bb789171b244032abc352a4136a7d37
- Source dataset
- uspto-grants-2011_11
- Patent number
- US08058431B2
Reaction notes
Loading…