Methyl iodide → 6-Methoxy-1-methyl-4-methylsulfanyl-2-phenyl-quinazolin-1-ium iodide

HRID 557135Notes

Reaction equation

HRID 557135 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH3:13])[C:8]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[N:7][C:6]2=[S:20].[CH3:21][I:22]>>[I-:22].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N+:9]([CH3:13])=[C:8]([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[N:7]=[C:6]2[S:20][CH3:21]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 866355316-Methoxy-1-methyl-2-phenyl-1H-quinazolin-4-thione

Product 1

HCID 669915126-Methoxy-1-methyl-4-methylsulfanyl-2-phenyl-quinazolin-1-ium iodide

Procedure

1.00 g (3.54 mmol) 6-Methoxy-1-methyl-2-phenyl-1H-quinazolin-4-thione was slowly added to 5 ml (80 mmol) methyl iodide at 0° C. and stirred for 1 h at room temperature. The solution was filtrated and the residue washed with ethyl ether and dichloromethane.

Workup

  1. filtrationThe solution was filtrated
  2. washthe residue washed with ethyl ether and dichloromethane

Sources & evidence

ORD record
ord-787b722ca06a4837ae8704090947c732
Source dataset
uspto-grants-2011_11
Patent number
US08058431B2

Reaction notes

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