HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 557141Generated: October 29, 2026
Ammonia → 3-Methylamino-thiophene-2-carboxylic acid amide
https://huagongshe.com/reaction/557141
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-methyl-1H,2H,4H-thieno[3,2-d][1,3]oxazine-2,4-dione | HCID 13683085 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Methylamino-thiophene-2-carboxylic acid amide | HCID 18358993 | — |
Reaction Steps
2.60 g (14.2 mmol) 1-Methyl-1H-thieno(3,2-d)(1,3)oxazine-2,4-dione were dissolved in 30 ml tetrahydrofuran and 15.0 ml ammonia (25%) were added at 0° C. The solution was stirred for 30 min at 0° C. and for 30 min at room temperature. THF was distilled under vacuum and the remaining suspension was neutralized with diluted hydrogen chloride acid. The product was isolated by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08058431B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-ed3cb71c625745dcaa6a288ca4384f77 |
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| Source note | uspto-grants-2011_11 |
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