Ammonia → 3-Methylamino-thiophene-2-carboxylic acid amide

HRID 557141Notes

Reaction equation

HRID 557141 reaction equation
[CH3:1][N:2]1[C:7]2[CH:8]=[CH:9][S:10][C:6]=2[C:5](=O)[O:4]C1=O.[NH3:13]>O1CCCC1>[CH3:1][NH:2][C:7]1[CH:8]=[CH:9][S:10][C:6]=1[C:5]([NH2:13])=[O:4]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 136830851-methyl-1H,2H,4H-thieno[3,2-d][1,3]oxazine-2,4-dione

Product 1

HCID 183589933-Methylamino-thiophene-2-carboxylic acid amide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

2.60 g (14.2 mmol) 1-Methyl-1H-thieno(3,2-d)(1,3)oxazine-2,4-dione were dissolved in 30 ml tetrahydrofuran and 15.0 ml ammonia (25%) were added at 0° C. The solution was stirred for 30 min at 0° C. and for 30 min at room temperature. THF was distilled under vacuum and the remaining suspension was neutralized with diluted hydrogen chloride acid. The product was isolated by filtration.

Workup

  1. distillationTHF was distilled under vacuum
  2. customThe product was isolated by filtration

Sources & evidence

ORD record
ord-ed3cb71c625745dcaa6a288ca4384f77
Source dataset
uspto-grants-2011_11
Patent number
US08058431B2

Reaction notes

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