Sodium Bicarbonate → HCID 11194669, compound

HRID 557237Notes

Reaction equation

HRID 557237 reaction equation
C(=O)([O-])O.[Na+].O.Cl.[C:8]([C:10]1[S:11][C:12]2[CH2:13][N:14]([CH3:19])[CH2:15][CH2:16][C:17]=2[N:18]=1)#[N:9]>O>[C:8]([C:10]1[S:11][C:12]2[CH2:13][N:14]([CH3:19])[CH2:15][CH2:16][C:17]=2[N:18]=1)#[N:9]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 23135439HCID 23135439, compound

Product 1

HCID 11194669HCID 11194669, compoundYield 100.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of sodium hydrogencarbonate (272.33 mg) in water (5 mL) was added to 2-cyano-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine hydrochloride monohydrate (500.30 mg) at room temperature, and after all ingredients were completely dissolved, the resultant solution was extracted with toluene three times (10 mL×3). The toluene layers were combined, and the combined toluene layer was dried over sodium sulfate anhydrate (2.00 g). After any insoluble material was filtered off, the filtrate was concentrated at 40° C. under reduced pressure, to thereby give 384.28 mg of the title compound.

Workup

  1. dissolutionafter all ingredients were completely dissolved
  2. extractionthe resultant solution was extracted with toluene three times (10 mL×3)
  3. dry with materialthe combined toluene layer was dried over sodium sulfate anhydrate (2.00 g)
  4. filtrationAfter any insoluble material was filtered off
  5. concentrationthe filtrate was concentrated at 40° C. under reduced pressure

Sources & evidence

ORD record
ord-1c071cef84cf4e0e8180e279cfb095fc
Source dataset
uspto-grants-2011_11
Patent number
US08058440B2

Reaction notes

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