HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 557261Generated: October 25, 2026
Acetic Acid → (E)-2-((4-(2-Nitrovinyl)benzyl)oxy)pyridine
https://huagongshe.com/reaction/557261
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 4-((Pyridin-2-yloxy)methyl)benzaldehyde | HCID 59255118 | — |
| Solvent | Water | HCID 962 | — |
| Product | (E)-2-((4-(2-Nitrovinyl)benzyl)oxy)pyridine | HCID 58076258 | — |
Reaction Steps
A mixture of 4-(pyridin-2-yloxymethyl)-benzaldehyde described in Preparation Example 1-3-2 (23.4 g, 110 mmol), nitro methane (33.6 g, 550 mmol), ammonium acetate (17.0 g, 220 mmol) and acetic acid (200 mL) was stirred at 100° C for one hour 45 minutes. While the reaction solution was being stirred under ice cooling, small amount of water was added thereto, and the precipitated solids were filtered to obtain title compound (21.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08058444B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-9f0d9889a1b54017bb63e14bfec34e84 |
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| Source note | uspto-grants-2011_11 |
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