反应详情

温度

100 °C

A mixture of 4-(pyridin-2-yloxymethyl)-benzaldehyde described in Preparation Example 1-3-2 (23.4 g, 110 mmol), nitro methane (33.6 g, 550 mmol), ammonium acetate (17.0 g, 220 mmol) and acetic acid (200 mL) was stirred at 100° C for one hour 45 minutes. While the reaction solution was being stirred under ice cooling, small amount of water was added thereto, and the precipitated solids were filtered to obtain title compound (21.0 g).

1. stirringWhile the reaction solution was being stirred under ice cooling
2. filtrationthe precipitated solids were filtered