反应详情

3-(3-(4-(Pyridin-2-yloxymethyl)-benzyl)-isoxazol-5-yl)-pyridin-2-yl amine (1 g) was dissolved in methanol (50 mL), and concentrated hydrochloric acid (1.18 mL) was added thereto at room temperature. This mixed solution was stirred at room temperature for 5 minutes, and then concentrated under a reduced pressure. To the residue were added ethanol and tert-butyl methyl ether, and subjected to ultrasound treatment. The precipitated solids were filtered, washed with tert-butyl methyl ether and dried in vacuo to obtain the title compound (908 mg).

1. customat room temperature
2. concentrationconcentrated under a reduced pressure
3. additionTo the residue were added ethanol and tert-butyl methyl ether
4. filtrationThe precipitated solids were filtered
5. washwashed with tert-butyl methyl ether
6. customdried in vacuo