反应详情

3-(3-(4-(Pyridin-2-yloxymethyl)-benzyl)-isoxazol-5-yl)-pyridin-2-yl amine (65 mg) was dissolved in methanol (0.87 mL) and ethyl acetate (0.87 mL), and phosphoric acid (85%, 0.013 mL) was added thereto. The solvent was concentrated under a reduced pressure, to the residue was added ethanol (4.3 mL), and dissolved by heating. Then, after filtration, the solution was left at room temperature to be solidified. The solids were filtered to obtain the title compound (31 mg).

1. concentrationThe solvent was concentrated under a reduced pressure, to the residue
2. additionwas added ethanol (4.3 mL)
3. dissolutiondissolved
4. temperatureby heating
5. filtrationThen, after filtration
6. waitthe solution was left at room temperature
7. filtrationThe solids were filtered