反应详情

温度

120 °C

A mix of 1-(tert-butyl)-2-bromo-4-nitrobenzene (3.652 g), TEA (5.92 ml), 3-buten-1-ol (5.48 ml), Pd(OAc)2 (32 mg), Pd(PPh3)4 (327 mg) and toluene (40 ml) was degassed with nitrogen and heated in a sealed vessel for 16 h at 120° C. The next day, the reaction mixture was cooled to RT, filtered, and concentrated in vacuo. The crude was eluted on a silica gel column with 15% to 22% EtOAc/hexanes gradient system to yield a yellow-brown oil.

1. customwas degassed with nitrogen
2. temperatureThe next day, the reaction mixture was cooled to RT
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. washThe crude was eluted on a silica gel column with 15% to 22% EtOAc/hexanes gradient system
6. customto yield a yellow-brown oil