反应详情

700 mg (3.7 mmol) of 2-methyl-4-oxo-4H-chromene-8-carbaldehyde are dissolved with 536 mg (3.7 mmol) of propyl 3-oxobutanoate, 205 mg (3.7 mmol) of 3-aminocrotononitrile and 223 mg (3.7 mmol) of acetic acid in 20 ml of 2-propanol and heated under reflux under argon for 16 h. The solvent is removed in vacuo, and the residue is purified by preparative HPLC. 460 mg (32% of theory) of the title compound are obtained as a yellow solid.

1. temperatureheated
2. temperatureunder reflux under argon for 16 h
3. customThe solvent is removed in vacuo
4. customthe residue is purified by preparative HPLC