Ethyl Acetoacetate → HCID 66991894, compound

HRID 557420Notes

Reaction equation

HRID 557420 reaction equation
[CH3:1][C:2]1[O:3][C:4]2[C:9]([C:10](=[O:12])[CH:11]=1)=[CH:8][CH:7]=[CH:6][C:5]=2[CH:13]=O.[C:15]([O:21][CH2:22][CH3:23])(=[O:20])[CH2:16][C:17]([CH3:19])=[O:18]>>[CH3:1][C:2]1[O:3][C:4]2[C:9]([C:10](=[O:12])[CH:11]=1)=[CH:8][CH:7]=[CH:6][C:5]=2[CH:13]=[C:16]([C:17](=[O:18])[CH3:19])[C:15]([O:21][CH2:22][CH3:23])=[O:20]

Participants

3

Reactant 2

HCID 8868Ethyl AcetoacetateHCID 133748832-Methyl-4-oxo-4H-chromene-8-carbaldehyde

Product 1

HCID 66991894HCID 66991894, compound

Procedure

The title compound is prepared in analogy to example 25 (stage 25a) starting from 2-methyl-4-oxo-4H-chromene-8-carbaldehyde (200 mg, 1.062 mmol) and ethyl acetoacetate (138 mg, 1.062 mmol). 309 mg (97% of theory) of the title compound are obtained as an E/Z isomer mixture.

Workup

  1. customThe title compound is prepared in analogy to example 25 (stage 25a)

Sources & evidence

ORD record
ord-46ee4d44299c4897848f01fe3e90a2d4
Source dataset
uspto-grants-2011_11
Patent number
US08058447B2

Reaction notes

Loading…