反应详情

150 mg (0.79 mmol) of 2-methyl-4-oxo-4H-chromene-8-carbaldehyde are dissolved with 84 mg (0.79 mmol) of sodium 1-cyanoprop-1-en-2-olate, 133 mg (0.79 mmol) of 4-amino-1-cyclopentylpent-3-en-2-one and 68 μl (1.19 mmol) of acetic acid in 4 ml of 2-propanol and heated under reflux under argon for 4 h. After cooling, the suspension is filtered with suction and the remaining solid is washed with diethyl ether (20 ml). 240 mg (75% of theory) of the title compound are obtained as a white solid.

1. temperatureheated
2. temperatureunder reflux under argon for 4 h
3. temperatureAfter cooling
4. filtrationthe suspension is filtered with suction
5. washthe remaining solid is washed with diethyl ether (20 ml)