反应详情

100 g (0.55 moles) of 4-hydroxy carbazole is dissolved in 600 ml of acetone. To that 188 g (1.36 moles) potassium carbonate, 2.0 g potassium iodide and 0.5 g sodium dithionate are added under nitrogen. The reaction mass is refluxed for 1.0 hr, cooled to room temperature followed by the addition of 150 g (1.62 moles) of epichlorohydrin through a dropping funnel over 40-45 min at room temp. The reaction mass is further refluxed for 32 hrs and then cooled to room temp and filtered. The above filtrate is evaporated followed by recrystallisation of the crude product from methanol.

1. temperatureThe reaction mass is refluxed for 1.0 hr
2. temperatureThe reaction mass is further refluxed for 32 hrs
3. temperaturecooled to room temp
4. filtrationfiltered
5. customThe above filtrate is evaporated
6. customfollowed by recrystallisation of the crude product from methanol