Aluminum(III) Chloride → 1-Acetyl-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline-6-carboxylic acid methyl ester

HRID 557571Notes

Reaction equation

HRID 557571 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]([C:15](=[O:17])[CH3:16])[C:10]([CH3:19])([CH3:18])[CH:9]=[C:8]2[CH3:20])=[O:4].[Al+3].[Cl-].[Cl-].[Cl-]>C1C=CC=CC=1>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]([C:15](=[O:17])[CH3:16])[C:10]([CH3:19])([CH3:18])[CH2:9][C:8]2([C:5]1[CH:6]=[CH:7][CH:12]=[CH:13][CH:14]=1)[CH3:20])=[O:4]

Participants

4

Reactant 2

HCID 6451240Aluminum(III) ChlorideHCID 669924781-Acetyl-1,2-dihydro-2,2,4-trimethylquinoline-6-carboxylic acid methyl ester

Product 1

HCID 669924761-Acetyl-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline-6-carboxylic acid methyl ester

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Friedel-Crafts alkylation of benzene (60 ml) with 1-acetyl-1,2-dihydro-2,2,4-trimethylquinoline-6-carboxylic acid methyl ester (2.3 g) in the presence of AlCl3 (4.4 g) was performed according to the method described in example 3.

Sources & evidence

ORD record
ord-7e46ca645eb5454e989cb32740c6a05b
Source dataset
uspto-grants-2011_11
Patent number
US08058441B2

Reaction notes

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