Pyridine → HCID 11283470, compound

HRID 557591Notes

Reaction equation

HRID 557591 reaction equation
[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([NH2:15])=[C:11]([CH3:14])[CH:12]=2)[C:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)([CH3:16])[CH2:6][C:5]1([CH3:24])[CH3:23])(=[O:3])[CH3:2].[C:25]1([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH:30]=[CH:29][C:28]([C:31](Cl)=[O:32])=[CH:27][CH:26]=1.N1C=CC=CC=1>O1CCCC1>[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([NH:15][C:31](=[O:32])[C:28]3[CH:29]=[CH:30][C:25]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)=[CH:26][CH:27]=3)=[C:11]([CH3:14])[CH:12]=2)[C:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)([CH3:16])[CH2:6][C:5]1([CH3:24])[CH3:23])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 1049PyridineHCID 841514-Phenylbenzoyl chlorideHCID 17962932HCID 17962932, compound

Product 1

HCID 11283470HCID 11283470, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Acylation of 1-acetyl-6-amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4,7-tetramethylquinoline (20 mg) with 4-biphenylcarbonyl chloride (100 mg) and pyridine (100 l) in tetrahydrofuran (5 ml) was performed according to the method described in example 6.

Sources & evidence

ORD record
ord-f76fb144d0c1481e846e5f25cba5e4a0
Source dataset
uspto-grants-2011_11
Patent number
US08058441B2

Reaction notes

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