Pyridine → HCID 11203161, compound

HRID 557592Notes

Reaction equation

HRID 557592 reaction equation
[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([NH2:16])=[CH:11][C:12]=2[O:14][CH3:15])[C:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([CH3:17])[CH2:6][C:5]1([CH3:25])[CH3:24])(=[O:3])[CH3:2].[C:26]1([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH:31]=[CH:30][C:29]([C:32](Cl)=[O:33])=[CH:28][CH:27]=1.N1C=CC=CC=1>O1CCCC1>[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([NH:16][C:32](=[O:33])[C:29]3[CH:30]=[CH:31][C:26]([C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)=[CH:27][CH:28]=3)=[CH:11][C:12]=2[O:14][CH3:15])[C:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([CH3:17])[CH2:6][C:5]1([CH3:25])[CH3:24])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 1049PyridineHCID 841514-Phenylbenzoyl chlorideHCID 17962882HCID 17962882, compound

Product 1

HCID 11203161HCID 11203161, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Acylation of 1-acetyl-6-amino-8-methoxy-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (20 mg) with 4-biphenylcarbonyl chloride (100 mg) and pyridine (100 μl) in tetrahydrofuran (5 ml) was performed according to the method described in example 6.

Sources & evidence

ORD record
ord-24f8688f780f4f818f3d52e47c890c50
Source dataset
uspto-grants-2011_11
Patent number
US08058441B2

Reaction notes

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