Trifluoroacetic acid → 1-[4-(1H-pyrazol-1-yl)phenyl]cyclopropane-1-carboxylic acid

HRID 557815Notes

Reaction equation

HRID 557815 reaction equation
FC(F)(F)C(O)=O.[N:8]1([C:13]2[CH:18]=[CH:17][C:16]([C:19]3([C:22]([O:24]CCCC)=[O:23])[CH2:21][CH2:20]3)=[CH:15][CH:14]=2)[CH:12]=[CH:11][CH:10]=[N:9]1>C(Cl)Cl>[N:8]1([C:13]2[CH:14]=[CH:15][C:16]([C:19]3([C:22]([OH:24])=[O:23])[CH2:21][CH2:20]3)=[CH:17][CH:18]=2)[CH:12]=[CH:11][CH:10]=[N:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66661840butyl 1-[4-(1H-pyrazol-1-yl)phenyl]cyclopropanecarboxylate

Product 1

HCID 666624111-[4-(1H-pyrazol-1-yl)phenyl]cyclopropane-1-carboxylic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (1.0 mL) was added to butyl 1-[4-(1H-pyrazol-1-yl)phenyl]cyclopropanecarboxylate (60 mg) in methylene chloride (1.0 mL). The mixture was stirred at room temperature overnight, and then concentrated to give a crude product which was directly used in the reaction of next step without further purification.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-e6a5b84ba593462498ec2451227971c9
Source dataset
uspto-grants-2011_11
Patent number
US08058288B2

Reaction notes

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