反应详情

A mixture of methyl 1-[4-(chloroacetyl)phenyl]cyclopropanecarboxylate (0.30 g, 1.2 mmol) and thiourea (0.18 g, 2.4 mmol) in ethanol (5.0 ml) was refluxed overnight. The reaction mixture was diluted with ethyl acetate and washed with saturated NaHCO3 and brine successively; then dried; and then concentrated. The residue was tritrurated with ether followed by filtration to afford the product. LC-MS: 275.1 (M+H)+.

1. temperaturewas refluxed overnight
2. washwashed with saturated NaHCO3 and brine successively
3. customthen dried
4. concentrationand then concentrated
5. filtrationfollowed by filtration
6. customto afford the product