Hydrochloric Acid → 1-(4-Aminophenyl)cyclopropanecarboxylic acid

HRID 557891Notes

Reaction equation

HRID 557891 reaction equation
Cl.C(OC([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2([C:19]([O:21]C(C)(C)C)=[O:20])[CH2:18][CH2:17]2)=[CH:12][CH:11]=1)=O)(C)(C)C>O1CCOCC1>[NH2:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2([C:19]([OH:21])=[O:20])[CH2:18][CH2:17]2)=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66662442Tert-butyl1-{4-[(tert-butoxycarbonyl)amino]phenyl}cyclopropanecarboxylate

Product 1

HCID 666623781-(4-Aminophenyl)cyclopropanecarboxylic acid

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4.0 M HCl in dioxane was added to tert-butyl 1-{4-[(tert-butoxycarbonyl)amino]phenyl}cyclopropanecarboxylate (160 mg, 0.00048 mol). After stirring at rt for 2 h, the volatiles were removed in-vacuo and the resulting residue was used in the next step without further purification.

Workup

  1. customthe volatiles were removed in-vacuo
  2. customthe resulting residue was used in the next step without further purification

Sources & evidence

ORD record
ord-4f97c3f0d42d4265a9a2580cee74fb05
Source dataset
uspto-grants-2011_11
Patent number
US08058288B2

Reaction notes

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