Methanol → HCID 66662131, compound

HRID 557896Notes

Reaction equation

HRID 557896 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH:8]1[CH2:12][CH:11]=[C:10]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)[CH2:9]1.CO>[Pt](=O)=O>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH:8]1[CH2:12][CH2:11][CH:10]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)[CH2:9]1

Participants

4

Reactant 2

HCID 887MethanolHCID 66662243HCID 66662243, compound

Product 1

HCID 66662131HCID 66662131, compound

Reagents, catalysts & solvents 1

HCID 345198Adams' catalystCatalyst

Procedure

To a solution of 2-(2,5-dihydro-1H-pyrrol-3-yl)-1,3-thiazole trifluoroacetate (2.49 g, 0.00936 mol) in methanol (100.0 mL, 2.469 mol) was added platinum dioxide (320 mg, 0.0014 mol) and the resulting mixture was hydrogenated on par shaker at 56 psi for 3 h. After filtration, the filtrate was concentrated in vacuo and dried under high vacuum to give the desired product as a solid. LC-MS (M+H) 155.2 (base).

Workup

  1. filtrationAfter filtration
  2. concentrationthe filtrate was concentrated in vacuo
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-c6c4f8482e374c4a85b251bdee17d2cb
Source dataset
uspto-grants-2011_11
Patent number
US08058288B2

Reaction notes

Loading…