反应详情

温度

0 °C

Lithium tetrahydroaluminate in tetrahydrofuran (1.00 M, 1.50 mL) was added to a solution of 2-benzyl-2,3,3a,9b-tetrahydrochromeno[3,4-c]pyrrol-4(1H)-one (188.0 mg, 0.0006730 mol) in THF (2.0 mL) at 0° C. The mixture was stirred at 0° C. for 1 h and then quenched with acetone. Ethyl acetate (10 mL) was added and the resulting mixture was treated with NaOH (1N, 3 mL) and then was filtered through a pad of celite. The filtrate was washed with brine (2×5 mL) and the organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure to give the desired product.

1. customquenched with acetone
2. additionEthyl acetate (10 mL) was added
3. additionthe resulting mixture was treated with NaOH (1N, 3 mL)
4. filtrationwas filtered through a pad of celite
5. washThe filtrate was washed with brine (2×5 mL)
6. dry with materialthe organic layer was dried over Na2SO4
7. filtrationfiltered
8. concentrationconcentrated under reduced pressure