Hydrochloric Acid → 8-(Methylsulfonyl)-2,8-diazaspiro[4.5]decane hydrochloride

HRID 557934Notes

Reaction equation

HRID 557934 reaction equation
[ClH:1].[CH3:2][S:3]([N:6]1[CH2:22][CH2:21][C:9]2([CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[CH2:8][CH2:7]1)(=[O:5])=[O:4]>O1CCOCC1>[ClH:1].[CH3:2][S:3]([N:6]1[CH2:7][CH2:8][C:9]2([CH2:13][NH:12][CH2:11][CH2:10]2)[CH2:21][CH2:22]1)(=[O:4])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 666627142,8-Diazaspiro[4.5]decane-2-carboxylic acid, 8-(methylsulfonyl)-, 1,1-dimethylethyl ester

Product 1

HCID 179736148-(Methylsulfonyl)-2,8-diazaspiro[4.5]decane hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Hydrogen chloride in 1,4-dioxane (4.0M, 0.50 mL) was added to tert-butyl 8-(methylsulfonyl)-2,8-diazaspiro[4.5]decane-2-carboxylate (21.0 mg, 0.0000659 mol) at rt. The mixture was stirred at rt for 1 h and then the solvent was evaporated. and the residue was dried under high vacuum to afford the desired product. LCMS: m/z 255.5 (M+H)+

Workup

  1. customthe solvent was evaporated
  2. customand the residue was dried under high vacuum

Sources & evidence

ORD record
ord-569fee1913a64c31be1acdf081a037f5
Source dataset
uspto-grants-2011_11
Patent number
US08058288B2

Reaction notes

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