Methanol → HCID 11609792, compound

HRID 557941Notes

Reaction equation

HRID 557941 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]([N:13]3[CH2:17][CH:16]=[C:15]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[CH3:24])[CH2:14]3)=[O:12])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.CO>[Pd].[O-]S([O-])(=O)=O.[Ba+2]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]([N:13]3[CH2:17][CH2:16][CH:15]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[CH3:24])[CH2:14]3)=[O:12])[CH2:9][CH2:10]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 66661949HCID 66661949, compound

Product 1

HCID 11609792HCID 11609792, compound

Reagents, catalysts & solvents 1

HCID 16218511Pd barium sulfateCatalyst

Procedure

To a solution of 1-{[1-(4-chlorophenyl)cyclopropyl]carbonyl}-3-(2-methylphenyl)-2,5-dihydro-1H-pyrrole (5 mg, 0.00001 mol) in methanol (1 mL, 0.02 mol) was added Pd/BaSO4 (reduced) and the mixture was stirred under an atmosphere of hydrogen at rt for 1 h. The crude product was purified using prep-HPLC. LCMS: m/z 340.4 (M+H)+

Workup

  1. customThe crude product was purified

Sources & evidence

ORD record
ord-88a5dc09997c4f908793bc6858a38a3d
Source dataset
uspto-grants-2011_11
Patent number
US08058288B2

Reaction notes

Loading…