Hydrochloric Acid → Methyl [(3-phenylpyrrolidin-3-yl)oxy]acetate

HRID 557947Notes

Reaction equation

HRID 557947 reaction equation
[CH3:1][O:2][C:3](=[O:24])[CH2:4][O:5][C:6]1([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]1.Cl>O1CCOCC1>[C:18]1([C:6]2([O:5][CH2:4][C:3]([O:2][CH3:1])=[O:24])[CH2:10][CH2:9][NH:8][CH2:7]2)[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66662708Tert-butyl 3-(2-methoxy-2-oxoethoxy)-3-phenylpyrrolidine-1-carboxylate

Product 1

HCID 86613966Methyl [(3-phenylpyrrolidin-3-yl)oxy]acetate

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl 3-(2-methoxy-2-oxoethoxy)-3-phenylpyrrolidine-1-carboxylate (160 mg, 0.00048 mol) was added 4 M of hydrogen chloride in 1,4-dioxane (1 mL) and the resulting solution was stirred for 1 h. The reaction mixture was then concentrated in-vacuo and the crude product was used directly in the next step.

Workup

  1. concentrationThe reaction mixture was then concentrated in-vacuo

Sources & evidence

ORD record
ord-044a90fa7fbf45528c76dad9c684f610
Source dataset
uspto-grants-2011_11
Patent number
US08058288B2

Reaction notes

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