反应详情

A 20-L pilot plant equipped with a mechanical stirrer and a nitrogen inlet was charged with NHS-carbonate, 1-S-[[[(isobutyryloxy)isobutyroxy]carbonyl]oxy]-2,5-pyrrolidinedione (20b), 1.31 kg, 4.7 mol) and (R)-baclofen (431 g; overall 1.2 eq. of R-baclofen) in a mixture of methyl tert-butyl ether (MTBE) and water (3:1; 10 L). The resulting suspension is stirred for 24 hours at room temperature.

1. customA 20-L pilot plant equipped with a mechanical stirrer and a nitrogen inlet