反应详情

Mix 2-(2-bromo-4-fluoro-phenyl)-2-methyl-propionitrile (1 g, 4.13 mmol) and 1,4,7,10,13,16-hexaoxacyclooctadecane (18-crown-6) (100 mg, 1% wt) with sodium hydroxide (10 M, 20 mL, 200 mmol) in ethanol (5 mL). Heat the mixture to reflux for 3 h. Quench the reaction with 1 N HCl. Extract the product with chloroform. Dry the organic phase over sodium sulfate and concentrate to give an oily residue. Purify the residue by FCC (10% methanol in DCM as eluant) to give the title compound as a yellow solid (1 g, 93%). MS (ES) m/z 260/262 [M+1]+.

1. temperatureHeat the mixture
2. temperatureto reflux for 3 h
3. customQuench
4. customthe reaction with 1 N HCl
5. extractionExtract the product with chloroform
6. dry with materialDry the organic phase over sodium sulfate
7. concentrationconcentrate
8. customto give an oily residue
9. customPurify the residue by FCC (10% methanol in DCM as eluant)