反应详情

温度

81 °C

Combine 2-bromo-1-bromomethyl-4-fluoro-benzene (4 g, 14.9 mmol), morpholine (2.6 mL, 29.8 mmol), and diisopropylethylamine (5.2 mL, 29.8 mmol) in acetonitrile (10.0 mL). Heat the reaction mixture at 81° C. for 2 h and cool to RT. Remove the solvent under reduced pressure. Dilute with DCM and wash with water and then aqueous saturated sodium chloride. Dry the organics over sodium sulfate. Filter and remove the solvent under reduced pressure to obtain the title compound (3.9 g, 95%). LCMS (ES) m/z 274 [M+1]+.

1. temperaturecool to RT
2. customRemove the solvent under reduced pressure
3. additionDilute with DCM
4. washwash with water
5. dry with materialDry the organics over sodium sulfate
6. filtrationFilter
7. customremove the solvent under reduced pressure