1-Tetralone → HCID 10495917, compound

HRID 558181Notes

Reaction equation

HRID 558181 reaction equation
[C:1]1(=[O:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[C:12]([O:21][CH2:22][CH3:23])(=[O:20])[C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:14]>>[O:11]=[C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH:2]1[C:13]([OH:14])([C:12]([O:21][CH2:22][CH3:23])=[O:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16]

Participants

3

Reactant 2

HCID 107241-TetraloneHCID 691051,3-Diethyl 2-oxopropanedioate

Product 1

HCID 10495917HCID 10495917, compoundYield 70.4%

Conditions

Temperature
100 °C

Procedure

A mixture of the required tetralone (0.01 mol) and diethyl mesoxalate (0.014 mol) was heated at 100° C. for 12 h. After cooling, the reaction mixture was purified by silica gel chromatography, eluting with cyclohexane/ethyl acetate (8/2), to give the white crystals. Yield 70.4%. ESI-MS: m/z 321.1 (M+H+).

Workup

  1. temperatureAfter cooling
  2. customthe reaction mixture was purified by silica gel chromatography
  3. washeluting with cyclohexane/ethyl acetate (8/2)
  4. customto give the white crystals

Sources & evidence

ORD record
ord-ffd927e953704d8191ce31b2e28c45f4
Source dataset
uspto-grants-2011_11
Patent number
US08063047B2

Reaction notes

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