HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 558247Generated: October 29, 2026
Dimethylacetamide → Methyl 7-(2-fluoro-4-iodophenylamino)-8-fluoro-4-methylquinazoline-6-carboxylate
https://huagongshe.com/reaction/558247
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | Formamide acetate | HCID 19966309 | — |
| Reactant | Methyl 5-acetyl-2-(2-fluoro-4-iodophenylamino)-3,4-difluorobenzoate | HCID 59519381 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Methyl 7-(2-fluoro-4-iodophenylamino)-8-fluoro-4-methylquinazoline-6-carboxylate | HCID 59519426 | 88% |
Reaction Steps
A mixture of methyl 5-acetyl-2-(2-fluoro-4-iodophenylamino)-3,4-difluorobenzoate (230 mg, 0.55 mmol) and formamide acetate (68 mg, 0.66 mmol) in DMA (5 ml) was heated at 95° C. for 6 hours. The reaction mixture was diluted with EtOAc and washed with water and brine. The organic layer was dried (MgSO4) and concentrated under reduced pressure to afford 205 mg (88%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08063049B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-aca568fcaea3456fbc57d82be22a4014 |
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| Source note | uspto-grants-2011_11 |
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