反应详情

温度

95 °C

A mixture of methyl 5-acetyl-2-(2-fluoro-4-iodophenylamino)-3,4-difluorobenzoate (230 mg, 0.55 mmol) and formamide acetate (68 mg, 0.66 mmol) in DMA (5 ml) was heated at 95° C. for 6 hours. The reaction mixture was diluted with EtOAc and washed with water and brine. The organic layer was dried (MgSO4) and concentrated under reduced pressure to afford 205 mg (88%) of the title compound.

1. washwashed with water and brine
2. dry with materialThe organic layer was dried (MgSO4)
3. concentrationconcentrated under reduced pressure