Triethylamine → HCID 178434620, compound

HRID 558271Notes

Reaction equation

HRID 558271 reaction equation
[CH3:1][S:2]([Cl:5])(=[O:4])=[O:3].[Cl:6][C:7]1[CH:8]=[C:9]([CH:12]=[C:13]([O:15][C:16]2[C:17]([CH3:28])=[N:18][NH:19][C:20]=2[CH2:21][N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH:14]=1)[C:10]#[N:11].C(N(CC)CC)C>ClCCl>[Cl:5][CH2:7][Cl:6].[CH3:13][OH:15].[NH3:11].[Cl:6][C:7]1[CH:8]=[C:9]([CH:12]=[C:13]([O:15][C:16]2[C:17]([CH3:28])=[N:18][NH:19][C:20]=2[CH2:21][N:22]2[CH2:23][CH2:24][N:25]([S:2]([CH3:1])(=[O:4])=[O:3])[CH2:26][CH2:27]2)[CH:14]=1)[C:10]#[N:11]

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 178434619HCID 178434619, compound

Product 2

HCID 21584172Ammonia methanol dichloromethaneHCID 178434620HCID 178434620, compoundYield 132.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methanesulphonyl chloride (19 μl, 0.240 mmol) was added dropwise to a stirred solution of the amine of Example 78 (80 mg, 0.240 mmol) and triethylamine (45 μL, 0.288 mmol) in dichloromethane (3 ml) at room temperature under nitrogen. The reaction was stirred for 30 minutes and then concentrated under reduced pressure to leave a yellow oil. The crude product was purified by flash column chromatography on silica gel eluting with dichloromethane and then dichloromethane:methanol:ammonia (95:4:1, by volume) to provide the title compound (65 mg) as a white foam.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customto leave a yellow oil
  3. customThe crude product was purified by flash column chromatography on silica gel eluting with dichloromethane

Sources & evidence

ORD record
ord-6b5f42476a0d4e0f8c25875b31e11d61
Source dataset
uspto-grants-2011_11
Patent number
US08063044B2

Reaction notes

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