反应详情

A solution of 6-methoxy-3-(trifluoromethyl)quinolin-2(1H)-one (4.60 g, 18.9 mmol) in POCl3 (30 mL) was refluxed for 2.5 hours. The solvent was removed under reduced pressure and the residue was neutralized by 2M NaOH to pH 7. An EtOAc workup was followed by removal of volatiles under reduced pressure. The residue was purified by column chromatography on silica gel (PE/EtOAc=15/1) to give the desired product (4.60 g, yield 94%).

1. customThe solvent was removed under reduced pressure
2. customAn EtOAc workup was followed by removal of volatiles under reduced pressure
3. customThe residue was purified by column chromatography on silica gel (PE/EtOAc=15/1)