Ammonium Hydroxide → 2-Chloro-4-methyl-1,3-thiazole-5-sulfonamide

HRID 558508Notes

Reaction equation

[Cl:1][C:2]1[S:3][C:4]([S:8](Cl)(=[O:10])=[O:9])=[C:5]([CH3:7])[N:6]=1.[OH-].[NH4+:13]>>[Cl:1][C:2]1[S:3][C:4]([S:8]([NH2:13])(=[O:10])=[O:9])=[C:5]([CH3:7])[N:6]=1

Participants

Reactant 2

HCID 14923Ammonium Hydroxide

HCID 120942502-Chloro-4-methyl-1,3-thiazole-5-sulfonyl chloride

Product 1

HCID 120942512-Chloro-4-methyl-1,3-thiazole-5-sulfonamideYield 88.2%

Procedure

Prepared by general procedure III from 2-Chloro-4-methyl-thiazole-5-sulfonyl chloride (1.0 g, 4 mmol,) and ammonium hydroxide (0.32 mL, 4 mmol) to give 2-Chloro-4-methyl-thiazole-5-sulfonic acid amide (0.75 g, 81%) as a white solid. MS (ISP) 213.0 [(M+H)+], 215.1 [(M+2+H)+].

Sources & evidence

ORD record: ord-5637499982884235ab3262d272bbce0b
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063048B2

Reaction notes

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