2-Amino-2-methyl-1-propanol → 5-chloro-N-(1-hydroxy-2-methylpropan-2-yl)thiophene-2-sulfonamide

HRID 558509Notes

Reaction equation

HRID 558509 reaction equation
[Cl:1][C:2]1[S:6][C:5]([S:7](Cl)(=[O:9])=[O:8])=[CH:4][CH:3]=1.[NH2:11][C:12]([CH3:16])([CH3:15])[CH2:13][OH:14]>>[OH:14][CH2:13][C:12]([NH:11][S:7]([C:5]1[S:6][C:2]([Cl:1])=[CH:3][CH:4]=1)(=[O:9])=[O:8])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 27339255-Chlorothiophene-2-sulfonyl chloride

Product 1

HCID 225008235-chloro-N-(1-hydroxy-2-methylpropan-2-yl)thiophene-2-sulfonamideYield 77.2%

Procedure

Prepared by general procedure III from commercially available 5-chloro-thiophene-2-sulfonyl chloride (1.0 g, 4.61 mmol) and 2-amino-2-methyl-1-propanol (1.23 g, 13.8 mmol) to give the title compound (0.96 g, 77%) as a white solid. MS (ISN) 268.1 [(M−H)−], mp 112° C.

Sources & evidence

ORD record
ord-8848c1ed723e44d99224a9e633b29299
Source dataset
uspto-grants-2011_11
Patent number
US08063048B2

Reaction notes

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