反应详情

温度

60 °C

To a solution of 4-bromo-2-fluorobenzoic acid (4 g, 18 mmol) in methanol (10 mL) was added dropwise oxalyl dichloride (4.6 g, 36 mmol). The reaction was heated to 60° C. overnight and added slowly into ice water, and extracted with DCM (50 mL×2). The combined extracts were washed with brine, dried over Na2SO4 and concentrated to give the desired product (3.7 g, 88%) as brown solid.

1. extractionextracted with DCM (50 mL×2)
2. washThe combined extracts were washed with brine
3. dry with materialdried over Na2SO4
4. concentrationconcentrated