反应详情

Compound 36 (178 mg, 0.75 mmol) was added to Pd/C (20 mg) in ethanol (5 mL), followed by ammonium formate (237 mg, 3.76 mmol) and the reaction mixture heated to reflux for 1 h. The reaction mixture was filtered through celite and the filtrate evaporated. The residue was dissolved in dichloromethane (20 mL) and washed with saturated sodium bicarbonate (20 mL). The organic phase was passed through a hydrophobic frit and evaporated to give the title compound as a yellow oil (155 mg, quant.; LCMS, Rt=0.32 min (MeOH-FA method), m/z 208 (MH+).

1. temperaturethe reaction mixture heated
2. temperatureto reflux for 1 h
3. filtrationThe reaction mixture was filtered through celite
4. customthe filtrate evaporated
5. dissolutionThe residue was dissolved in dichloromethane (20 mL)
6. washwashed with saturated sodium bicarbonate (20 mL)
7. customevaporated