4-Bromobenzyl alcohol → HCID 11852314, compound

HRID 558916Notes

Reaction equation

HRID 558916 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([OH:17])([CH3:16])[CH3:15])[N:11]3[N:18]=[CH:19][C:20]([C:21]#[CH:22])=[C:10]3[N:9]=2)=[CH:4][CH:3]=1.Br[C:24]1[CH:31]=[CH:30][C:27]([CH2:28][OH:29])=[CH:26][CH:25]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([OH:17])([CH3:16])[CH3:15])[N:11]3[N:18]=[CH:19][C:20]([C:21]#[C:22][C:24]4[CH:31]=[CH:30][C:27]([CH2:28][OH:29])=[CH:26][CH:25]=4)=[C:10]3[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 701194-Bromobenzyl alcoholHCID 86608078HCID 86608078, compound

Product 1

HCID 11852314HCID 11852314, compound

Procedure

The title compound was prepared from 2-[5-(4-chloro-phenyl)-3-ethynyl-pyrazolo[1,5-a]pyrimidin-7-yl]-propan-2-ol (example C.13) (78 mg, 0.25 mmol) and 4-bromobenzyl alcohol (47 mg, 0.25 mmol) according to general procedure II. Obtained as a yellow solid (16 mg, 15%). MS (ISP) 418.1 [(M+H)+].

Sources & evidence

ORD record
ord-5d663398581c44c99964f91febc4b4c5
Source dataset
uspto-grants-2011_11
Patent number
US08063048B2

Reaction notes

Loading…