HRID558957

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：Cc1cc(C(=O)N2CCCCc3ccccc32)ccc1CNC(=O)N1CC(=O)N(CC(=O)OC(C)(C)C)c2cccc(F)c21

HCID59807173

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C(=O)N2CCCCc3ccccc32)ccc1CNC(=O)N1CC(=O)N(CC(=O)O)c2cccc(F)c21

HCID11570214

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of {5-fluoro-4-[2-methyl-4-(2,3,4,5-tetrahydrobenzo[b]azepine-1-carbonyl)benzylcarbamoyl]-2-oxo-3,4-dihydro-2H-quinoxalin-1-yl}acetic acid tert-butyl ester from Example 7B (105 mg, 0.175 mmol) in dichloromethane (4.0 ml) was added trifluoroacetic acid (4.0 ml). The mixture was stirred for 1.5 h, evaporated in vacuo and azeotroped with toluene to give a white solid; yield 95 mg, 100%.

WORKUP

后处理

customevaporated in vacuo
customazeotroped with toluene
customto give a white solid

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bbb1a2d6a25d4e619e56fc861d79828e
来源数据集: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08063038B2
来源说明: uspto-grants-2011_11

反应 SMILES

C([O:5][C:6](=[O:44])[CH2:7][N:8]1[C:17]2[C:12](=[C:13]([F:18])[CH:14]=[CH:15][CH:16]=2)[N:11]([C:19](=[O:42])[NH:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]([N:30]3[CH2:36][CH2:35][CH2:34][CH2:33][C:32]4[CH:37]=[CH:38][CH:39]=[CH:40][C:31]3=4)=[O:29])=[CH:24][C:23]=2[CH3:41])[CH2:10][C:9]1=[O:43])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[F:18][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:12]=1[N:11]([C:19](=[O:42])[NH:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]([N:30]3[CH2:36][CH2:35][CH2:34][CH2:33][C:32]4[CH:37]=[CH:38][CH:39]=[CH:40][C:31]3=4)=[O:29])=[CH:24][C:23]=1[CH3:41])[CH2:10][C:9](=[O:43])[N:8]2[CH2:7][C:6]([OH:44])=[O:5]