反应详情

Following the same procedure as described for 1D, (5-chloro-2-oxo-3,4-dihydro-2H-quinoxalin-1-yl)acetic acid tert-butyl ester from Example 12E (450 mg, 1.5 mmol) was treated with phosgene (2.0 mmol) and diisopropylethylamine (2.0 mmol) followed by (4-aminomethyl-3-methylphenyl)-(2,3,4,5-tetrahydrobenzo[b]azepin-1-yl)methanone from Example F (450 mg, 1.5 mmol) and diisopropylethylamine (2.0 mmol). The product was purified by flash chromatography on silica (eluant pet.ether:EtOAC, 100:0 to 50:50) to give a pale red solid; yield 510 mg, 54%.

1. customThe product was purified by flash chromatography on silica (eluant pet.ether:EtOAC, 100:0 to 50:50)
2. customto give a pale red solid