1,4-Dioxane hydrochloride → HCID 11584727, compound

HRID 558971Notes

Reaction equation

HRID 558971 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][N:11]1[C:20]2[C:15](=[C:16]([F:21])[CH:17]=[CH:18][CH:19]=2)[N:14]([C:22](=[O:45])[NH:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]([N:33]3[CH2:39][CH2:38][CH2:37][CH2:36][C:35]4[CH:40]=[CH:41][CH:42]=[CH:43][C:34]3=4)=[O:32])=[CH:27][C:26]=2[CH3:44])[CH2:13][C:12]1=[O:46])(C)(C)C.Cl.O1CCOCC1>C1(C)C=CC=CC=1>[CH3:44][C:26]1[CH:27]=[C:28]([C:31]([N:33]2[CH2:39][CH2:38][CH2:37][CH2:36][C:35]3[CH:40]=[CH:41][CH:42]=[CH:43][C:34]2=3)=[O:32])[CH:29]=[CH:30][C:25]=1[CH2:24][NH:23][C:22]([N:14]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])[N:11]([CH2:10][CH2:9][CH2:8][NH2:7])[C:12](=[O:46])[CH2:13]1)=[O:45]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67000045HCID 67000045, compound

Product 1

HCID 11584727HCID 11584727, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

(3-{5-Fluoro-4-[2-methyl-4-(2,3,4,5-tetrahydrobenzo[b]azepine-1-carbonyl)-benzylcarbamoyl]-2-oxo-3,4-dihydro-2H-quinoxalin-1-yl}propyl)carbamic acid tert-butyl ester from Example 15B (90 mg, 0.14 mmol) was added to a solution of 4N HCl/dioxan (10 ml) and the mixture was stirred for 0.5 h. The mixture was diluted with toluene, evaporated in vacuo and azeotroped with toluene to give a pale yellow solid; yield 82 mg, 100%.

Workup

  1. customevaporated in vacuo
  2. customazeotroped with toluene
  3. customto give a pale yellow solid

Sources & evidence

ORD record
ord-c0648f115a654b6a9110963c4040085a
Source dataset
uspto-grants-2011_11
Patent number
US08063038B2

Reaction notes

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