反应详情

Amixture of 3-nitro-1-phenyl-1H-pyrrole (410 mg, 2.18 mmol) and SnCl2 dihydrate (2.00 g, 8.86 mmol) in EtOAc (15 mL) was stirred at 80 C for 3 h. Aqueous 1N NaOH was added to bring pH to 12. The mixture was filtered through celite. The organic phase was separated, washed with 5% NaHCO3, dried over Na2SO4, concentrated in vacuo to give 1-phenyl-1H-pyrrol-3-amine as a solid (323 mg).

1. filtrationThe mixture was filtered through celite
2. customThe organic phase was separated
3. washwashed with 5% NaHCO3
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo