2-Amino-2-thioxoethyl 2,2-dimethylpropanoate → 2,2-Dimethylpropionic acid 4-[3-(4-fluorophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indol-6-yl]-thiazol-2-ylmethyl ester

HRID 559164Notes

Reaction equation

HRID 559164 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[N:10]([CH3:14])[C:9]1[N:15]([CH3:27])[C:16](=[O:26])[C:17]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)=[CH:18][C:8]2=1)=O.[C:28]([O:34][CH2:35][C:36]([NH2:38])=[S:37])(=[O:33])[C:29]([CH3:32])([CH3:31])[CH3:30]>>[F:25][C:22]1[CH:21]=[CH:20][C:19]([C:17]2[C:16](=[O:26])[N:15]([CH3:27])[C:9]3[N:10]([CH3:14])[C:11]4[C:7]([C:8]=3[CH:18]=2)=[CH:6][C:5]([C:3]2[N:38]=[C:36]([CH2:35][O:34][C:28](=[O:33])[C:29]([CH3:32])([CH3:31])[CH3:30])[S:37][CH:2]=2)=[CH:13][CH:12]=4)=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 27821132-Amino-2-thioxoethyl 2,2-dimethylpropanoateHCID 866239516-(2-Bromoacetyl)-3-(4-fluorophenyl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one

Product 1

HCID 669978782,2-Dimethylpropionic acid 4-[3-(4-fluorophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indol-6-yl]-thiazol-2-ylmethyl ester

Procedure

The process is carried out as indicated in Example 3 above, with compound B 6-(2-bromoacetyl)-3-(4-fluorophenyl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one and 2-amino-2-thioxoethyl pivalate

Sources & evidence

ORD record
ord-1ad4a7fcd7154ebebf54cae4c7625c6b
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Reaction notes

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