Iodoethane → 6-(2-Ethoxymethylthiazol-4-yl)-3-(4-fluorophenyl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:28](=[O:29])[N:27]([CH3:30])[C:11]3[N:12]([CH3:26])[C:13]4[C:18]([C:10]=3[CH:9]=2)=[CH:17][C:16]([C:19]2[N:20]=[C:21]([CH2:24][OH:25])[S:22][CH:23]=2)=[CH:15][CH:14]=4)=[CH:4][CH:3]=1.I[CH2:32][CH3:33]>>[CH2:32]([O:25][CH2:24][C:21]1[S:22][CH:23]=[C:19]([C:16]2[CH:17]=[C:18]3[C:13](=[CH:14][CH:15]=2)[N:12]([CH3:26])[C:11]2[N:27]([CH3:30])[C:28](=[O:29])[C:8]([C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=4)=[CH:9][C:10]3=2)[N:20]=1)[CH3:33]Participants
3
Procedure
The process is carried out as in Example 10 above, using 3-(4-fluorophenyl)-6-(2-hydroxymethylthiazol-4-yl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one, compound from Example 63 and iodoethane.
Sources & evidence
- ORD record
- ord-27a7737ba4544c069e7e44c34f8e5431
- Source dataset
- uspto-grants-2011_11
- Patent number
- US08063061B2
Reaction notes
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