Hydrazine hydrate (1:1) → HCID 178468610, compound

HRID 559184Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:33])[C:5](=O)[CH2:6][C:7]([C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH3:18])[C:13]1[N:19]([CH3:31])[C:20](=[O:30])[C:21]([C:23]3[CH:28]=[CH:27][C:26]([Br:29])=[CH:25][CH:24]=3)=[CH:22][C:12]2=1)=O)[CH3:2].O.[NH2:35][NH2:36]>>[CH2:1]([O:3][C:4]([C:5]1[CH:6]=[C:7]([C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[N:14]([CH3:18])[C:13]2[N:19]([CH3:31])[C:20](=[O:30])[C:21]([C:23]4[CH:24]=[CH:25][C:26]([Br:29])=[CH:27][CH:28]=4)=[CH:22][C:12]3=2)[NH:36][N:35]=1)=[O:33])[CH3:2]

Participants

Reactant 2

HCID 24654Hydrazine hydrate (1:1)

HCID 669972784-[3-(4-Bromophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indol-6-yl]-2,4-dioxobutyric acid ethyl ester

Product 1

HCID 178468610HCID 178468610, compound

Procedure

The process is carried out as in Example 43 above, with compound A, 4-[3-(4-bromophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indol-6-yl]-2,4-dioxobutyric acid ethyl ester and hydrazine monohydrate.

Sources & evidence

ORD record: ord-d5432e6ea45f43b2847107715c4644bd
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063061B2

Reaction notes

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